Santa Clara, CA and Santa Fe, NM, August 6, 2008 In an extension of its strategic partnership, Symyx Technologies, Inc. (Nasdaq: SMMX) plans to integrate OpenEye’s Lexichem™ structurename converter software with Symyx Draw and other key solutions including the soon-to-be-released Symyx Isentris® 3.1 informatics system. This integration will enhance and accelerate chemical compound searching by enabling chemists to generate structures for query or other purposes simply by providing chemical names rather than drawing the structures. This time-saving capability initially will be incorporated into the upcoming release of the Symyx Draw structure editor.

"OpenEye products are complementary with Symyx solutions and by working together we will provide our customers with best-of-breed functionality," said Dr. Trevor Heritage, President of Symyx Software. "This partnership creates greater flexibility within discovery workflows through improved efficiency in converting chemical names to chemical structures and vice versa. We look forward to a long-standing relationship with our colleagues at OpenEye Scientific Software."

"With Symyx, OpenEye’s outstanding cheminformatics will gain a larger audience," said Dr. Matthew Stahl, Senior Vice President and Head of Strategic Development at OpenEye Scientific Software. "The breadth of Symyx software solutions and their diverse customer base presents us with an outstanding opportunity to further temper our software. It has been a pleasure working with an industry leader like Symyx, and we anticipate strengthening our relationship in the future."

As part of a continued program to extend the range of files supported by Symyx Draw software to include popular chemical structure formats, Symyx will incorporate file converters from OpenEye’s OEChem programming library for chemistry and cheminformatics into Symyx Draw. This integration will enable Symyx Draw to read and write ChemDraw (CDX), canonical SMILES™ and a number of other file formats.

As part of this agreement, Prous Science, part of the scientific business of Thomson Reuters, and Symyx are extending to OpenEye access to the MDDR database, the leading bioactivity database jointly produced by Symyx and the scientific business of Thomson Reuters, for use in validating OpenEye’s various scientific algorithms. OpenEye will also be able to validate their models against the well-known Symyx Comprehensive Medicinal Chemistry database (Elsevier).

About OpenEye Scientific Software, Inc.
OpenEye Scientific Software Inc. is a privately held company headquartered in Santa Fe, New Mexico, with offices in Boston, Massachusetts and Strasbourg, France. It was founded in 1997 to develop large-scale modeling applications and toolkits. Primarily geared towards drug discovery and design, areas of application include chemical informatics, structure generation, docking, shape comparison, charge & electrostatics and visualization. The software is designed for scientific rigor, as well as speed, scalability and platform independence. OpenEye makes most of its technology available as toolkits - programming libraries suitable for custom development. OpenEye software typically is distributable across multiple processors, supports 64-bit processing, and runs on Linux, Windows and Mac OS X, as well as IBM and SUN flavors of UNIX. For further information on the company and its products, see http://www.eyesopen.com
For more information, please contact: business@eyesopen.com

Symyx Technologies, Inc. is the scientific R&D integration partner to companies in the life sciences, chemicals, energy, electronics and consumer products industries. With scientific R&D under tremendous economic and technical pressure, we help companies reduce R&D risk and enhance R&D productivity to help them bring more and better products to market quickly and cost-effectively. Our integrated technology platform combines electronic laboratory notebooks, content, laboratory logistics and analysis available from Symyx Software, software-driven integrated workflows available from Symyx Tools and collaborative research and directed services from Symyx Research to support the entire R&D process. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.

Symyx and Isentris are registered trademarks of Symyx Technologies, Inc. All rights reserved. Lexichem is a trademark of OpenEye Scientific Software, Inc. Prous Science is a registered trademark in the United States of Prous Science, S.A.U. The MDDR database contains material belonging to Prous Science, S.A.U., © Copyright 1989-2008. SMILES is a trademark of Daylight Chemical Information Systems, Inc. All other trademarks mentioned in this document are the property of their respective owners.